Structural properties of acidic phospholipids in complexes with calcitonin : a Fourier transform infrared spectroscopic investigation

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DOIResolve DOI: http://doi.org/10.1016/0005-2736(87)90413-5
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TypeArticle
Journal titleBiochimica et Biophysica Acta (BBA) - Biomembranes
ISSN00052736
Volume899
Issue2
Pages307310
SubjectCalcitonin; Lipid-protein interaction; Phospholipid structure; Fourier transform infrared spectroscopy
AbstractThe interaction of the polypeptide hormone calcitonin with two acidic phospholipids, dimyristoylphosphatidylglycerol (DMPG) and dimyristoylphosphatidic acid (DMPA), was investigated by Fourier-transform infrared spectroscopy. The association of calcitonin with DMPG results in a broadening of the lipid phase transition, accompanied by a marked decrease in the conformational order of the acyl chains at temperatures below the phase transition region. Infrared bands due to carbonyl ester and phosphate group vibrations of DMPG molecules are not significantly affected by the presence of calcitonin. The effect of calcitonin on the conformation of acyl chains in DMPA is much smaller compared with DMPG. The different susceptibility of DMPG and DMPA to perturbation by calcitonin is suggested to be related to different degrees of intermolecular interactions between the headgroups of these two phospholipids.
Publication date
PublisherElsevier B.V.
LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedYes
NPARC number23001258
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Record identifierca8a8629-8f5c-458d-a32c-2fe568a879a6
Record created2017-01-12
Record modified2017-01-12
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