Microwave-assisted Kochetkov amination followed by permanent charge derivatization : A facile strategy for glycomics

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DOIResolve DOI: http://doi.org/10.1039/C0CC01732A
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TypeArticle
Journal titleChemical Communications
Volume46
Issue39
Pages74247426; # of pages: 3
AbstractWe report a simple and rapid microwave-assisted method for the preparation of oligosaccharide-glycosylamines, followed by labelling with tris(2,4,6-trimethoxyphenyl)phosphonium acetic acid N-hydroxysuccinimide ester. The facile strategy introduced a permanent charge at the reducing end of the oligosaccharide. In combination of MALDI-MS, the detection limit for maltoheptaose was as low as 2 fmol μL⁻¹.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17400938
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Record identifiercb27f614-7964-42aa-b071-ef247321d885
Record created2011-03-25
Record modified2016-05-09
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