The lipooligosaccharide of Campylobacter jejuni : similarity with multiple types of mammalian glycans beyond gangliosides

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DOIResolve DOI: http://doi.org/10.1074/jbc.M110.181750
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TypeArticle
Journal titleThe Journal of Biological Chemistry
Volume286
Pages1236112370; # of pages: 10
Subjectcarbohydrate biosynthesis; carbohydrate chemistry; carbohydrate structure; glycoconjugate; glycolipids; campylobacter; ganglioside; guillain-barre; lipooligosaccharide; lipopolysaccharide
AbstractCampylobacter jejuni is well known for synthesizing ganglioside mimics within the glycan component of its lipooligosaccharide (LOS), which have been implicated in triggering Guillain-Barre syndrome (GBS). We now confirm that this pathogen is capable of synthesizing a much broader spectrum of host glycolipid/glycoprotein mimics within its LOS. P-blood group and paragloboside (lacto-N-neotetraose) antigen mimicry is exhibited by RM1221, a strain isolated from a poultry source. RM1503, a gastroenteritis-associated strain, expresses lacto-N-biose and sialyl-Lewis c units, the latter known as the pancreatic tumor-associated antigen, DU-PAN-2 (or LSTa). C. jejuni GC149, a GBS-associated strain, expresses an unusual sialic acid-containing hybrid oligosaccharide with similarity to both ganglio and Pk antigens and can, through phase variation of its LOS biosynthesis genes, display GT1a or GD3 ganglioside mimics. We show that the sialyltransferase CstII, and the galactosyltransferase CgtD, are involved in the synthesis of multiple mimic types, with LOS structural diversity achieved through evolving allelic substrate specificity.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number19258806
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Record identifiercb5a6f53-0e3c-41f8-b26f-d99071a9c008
Record created2012-03-08
Record modified2016-05-09
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