Infrared spectroscopic characterization of the interaction of lipid bilayers with phenol, salicylic acid and o-acetylsalicylic acid

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DOIResolve DOI: http://doi.org/10.1016/0009-3084(87)90016-8
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TypeArticle
Journal titleChemistry and Physics of Lipids
ISSN0009-3084
Volume43
Issue1
Pages4753
Subjectmembrane; infrared; phenol; salicylic acid; o-acetylsalicylic acid
AbstractThe interaction of phenol (PHE), salicylic acid (SA) and o-acetylsalicylic acid (ASA) with bilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was investigated by infrared spectrometry. The temperature of the main gel to liquid crystal phase transition of DPPC is markedly depressed in the presence of the three guest molecules. The temperature depression depends on the nature and concentration of the additives. The temperature of the pretransition is also affected by these guest molecules and the depression in temperature is even more pronounced than that of the main transition temperature. Possible modes of interaction of these guest molecules with the lipid bilayers are discussed.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedYes
NPARC number23001416
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Record identifiercb713138-7bec-433e-aa45-0d7dcb45f03a
Record created2017-02-02
Record modified2017-02-02
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