Enhancement of bone consolidation in mandibular distraction osteogenesis: A contemporary review of experimental studies involving adjuvant therapies

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DOIResolve DOI: http://doi.org/10.1016/j.bjps.2013.03.030
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TypeArticle
Journal titleJournal of Plastic, Reconstructive and Aesthetic Surgery
ISSN1748-6815
Volume66
Issue7
Pages883895; # of pages: 13
Subjectadiponectin; alendronic acid; bone morphogenetic protein 2; bone morphogenetic protein 4; calcium hydroxide; calcium sulfate; deferoxamine; erythropoietin; fibroblast growth factor; icariin; nerve growth factor; osteogenic protein 1; simvastatin; somatomedin C; tissue inhibitor of metalloproteinase 1; zoledronic acid; angiogenesis; bone development; bone regeneration; distraction osteogenesis; electrostimulation; extracorporeal lithotripsy; gene therapy; human; hyperbaric oxygen; low intensity pulsed ultrasound; low level laser therapy; mandibular distraction osteogenesis; mechanical stimulation; membrane guided regeneration; mesenchymal stem cell; nonhuman; ossification; priority journal; protein expression; protein function; review; systematic review; ultrasound; Adjuvants, Pharmaceutic; Alendronate; Animals; Bone Morphogenetic Protein 4; Bone Regeneration; Disease Models, Animal; Dogs; Electric Stimulation Therapy; Erythropoietin; Genetic Therapy; Mandible; Nerve Growth Factor; Osteogenesis; Osteogenesis, Distraction; Rabbits; Rats; Risk Assessment; Stem Cell Transplantation; Treatment Outcome
AbstractBackground One of the major disadvantages of mandibular distraction osteogenesis (MDO) is the prolonged time required for consolidation of the regenerate bone. The objective of the present study is to perform a contemporary review of various adjuvant therapies to enhance bone consolidation in MDO. Methods A PubMed search for articles related to MDO, along with the references of those articles, was performed. Inclusion and exclusion criteria were applied to all experimental studies assessing adjuvant therapies to enhance bone consolidation. Results A total of 1414 titles and abstracts were initially reviewed; 61 studies were included for full review. Many studies involved growth factors, hormones, pharmacological agents, gene therapy, and stem cells. Other adjuvant therapies included mechanical stimulation, laser therapy, and hyperbaric oxygen. Majority of the studies demonstrated positive bone healing effects and thus adjuvant therapies remain a viable strategy to enhance and hasten the consolidation period. Conclusion Although most studies have demonstrated promising results, many questions still remain, such as optimal amount, timing, and delivery methods required to stimulate the most favorable bone regeneration. As well, further studies comparing various adjuvant therapies and documentation of long-term adverse effects are required prior to clinical application. © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biodiagnostics (IBD-IBD)
Peer reviewedYes
NPARC number21269944
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Record identifiercff5a645-eee7-492c-af6d-6c47c00c1c75
Record created2013-12-13
Record modified2016-05-09
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