Studies of multicomponent Kinugasa reactions in aqueous media

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DOIResolve DOI: http://doi.org/10.1016/j.tetlet.2009.02.035
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TypeArticle
Journal titleTetrahedron Letters
Volume50
Issue17
Pages18931896; # of pages: 3
SubjectC,N-diphenylnitrones; phenylacetylide; β-lactams; cycloaddition
AbstractMicelle-promoted, copper-catalyzed multicomponent Kinugasa reactions were studied in aqueous media. Reactions were performed in a ‘single pot’ for a series of in situ generated C,N-diphenylnitrones with Cu(I) phenylacetylide providing β-lactams in yields of 45–85%. Substituents affect the reaction by either accelerating cycloaddition or minimizing side reactions.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Steacie Institute for Molecular Sciences
Peer reviewedYes
NPARC number16080410
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Record identifierd27e9197-0e00-4611-9bd8-dfc347082501
Record created2010-09-21
Record modified2016-05-09
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