Natural-product-like chiral derivatives by solid-phase synthesis

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DOIResolve DOI: http://doi.org/10.1016/S1367-5931(00)00205-2
AuthorSearch for: ; Search for:
TypeArticle
Journal titleCurrent Opinion in Chemical Biology
Volume5
Issue3
Pages292301; # of pages: 10
Subjectchemical genetics; combinatorial chemistry; genomics; high-throughput; natural product; proteomics; solid-phase synthesis; stereoselective synthesis; total synthesis; Ugi
AbstractIn this genomics and proteomics age, highly functionalized natural products or natural-product-like compounds are likely to play important roles in understanding the functions of emerging biological targets because they serve as small-molecule chemical probes in modulating a target's specific actions (i.e. activation or deactivation). Development of stereoselective reaction-derived methods on solid phase provides a means of obtaining functionalized chiral core structures that may be used for high-throughout syntheses.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12328584
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Record identifierd40545ab-97e4-4f1a-8865-b62e55953993
Record created2009-09-10
Record modified2016-05-09
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