Combining nuclear magnetic resonance spectroscopy and mass spectrometry in biomarker discovery

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DOIResolve DOI: http://doi.org/10.2217/bmm.09.22
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TypeArticle
Journal titleBiomarkers in Medicine
Volume3
Issue3
Pages307322; # of pages: 16
Subjectcancer; cholangiocarcinoma; colon cancer; gallbladder cancer; gastric cancer; gastrointestinal; hepatobiliary diseases; hepatocellular carcinoma; mass spectrometry; metabolic profiling; metabolomics; multivariate statistical analysis; NMR spectroscopy; pancreatic cancer
AbstractMetabolic profiling of biological specimens is emerging as a promising approach for discovering specific biomarkers in the diagnosis of a number of diseases. Amongst many analytical techniques, nuclear magnetic resonance spectroscopy and mass spectrometry are the most information-rich tools that enable high-throughput and global analysis of hundreds of metabolites in a single step. Although only one of the two techniques is utilized in a majority of metabolomics applications, there is a growing interest in combining the data from the two methods to effectively unravel the mammoth complexity of biological samples. In this article, current developments in nuclear magnetic resonance, mass spectrometry and multivariate statistical analysis methods are described. While some general applications that utilize the combination of the two analytical methods are presented briefly, the emphasis is laid on the recent applications of nuclear magnetic resonance and mass spectrometry methods in the studies of hepatopancreatobiliary and gastrointestinal malignancies.
Publication date
LanguageEnglish
AffiliationNRC Industrial Research Assistance Program; NRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number19939767
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Record identifierd4e7e2e6-c101-4c4a-a019-e804fa1837f5
Record created2012-05-10
Record modified2016-05-09
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