A new approach for manufacturing and processing targets to produce 99mTc with cyclotrons

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DOIResolve DOI: http://doi.org/10.1142/S0217732317400119
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleModern Physics Letters A
ISSN0217-7323
1793-6632
Volume32
Issue17
Article number1740011
Pages# of pages: 14
Subject99mTc; cyclotron; target; target processing
AbstractThe most important radioisotope for nuclear medicine is 99mTc. After the supply crisis of 99Mo starting in 2008, the availability of 99mTc became a worldwide concern. Alternative methods for producing the medical imaging isotope 99m 99mTc are actively being developed around the world. The reaction 100 100Mo(p, 2n) 99mTc provides a direct route that can be incorporated into routine production in nuclear medicine centers that possess medical cyclotrons for production of other isotopes, such as those used for Positron Emission Tomography. This paper describes a new approach for manufacturing targets for the (p, 2n) nuclear reaction on 100Mo and the foundation for the subsequent commercial separation and purification of the 99mTc produced. Two designs of targets are presented. The targets used to produce 99mTc are subject to a number of operational constraints.They must withstand the temperatures generated by the irradiation, accommodate temperature gradients from cooling system of the target, must be resilient and must be easily post-processed to separate the 99mTc. After irradiation, the separation of Tc from Mo was carried out using an innovative two-step approach. The process described in this paper can be automated with modules that easily fit in standard production hot cells found in nuclear medicine facilities.
Publication date
PublisherWorld Scientific Publishing
LanguageEnglish
AffiliationMeasurement Science and Standards; National Research Council Canada
Peer reviewedYes
NPARC number23002356
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Record identifierd701bd8f-9420-441b-a47d-fa15f6876c5d
Record created2017-10-23
Record modified2017-10-23
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