A novel pectenotoxin, PTX-12, in Dinophysis Spp. and shellfish from Norway

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DOIResolve DOI: http://doi.org/10.1021/tx049870a
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TypeArticle
Journal titleChemical Research in Toxicology
Volume17
Issue11
Pages14231433; # of pages: 11
Subjectmass spectrometry; shellfish; Mytilus edulis; Norwegian blue mussels
AbstractTwo novel pectenotoxins (PTXs) were detected by LC-MS in solid phase extracts of net hauls taken at Fldevigen, Norway, in June 2002 that were dominated by Dinophysis acuminata and Dinophysis norvegica. The new compounds were isolated as minor components from a large collection of a Dinophysis acuta-dominated bloom obtained from Skjer, Sognefjorden, Norway, in October 2002. LC-MS and NMR analyses revealed that the new components, 36S-PTX-12 and 36R-PTX-12, occurred as a pair of equilibrating diastereoisomers differing from PTX-2 in that they contained an exocylic olefinic methylene rather than a methyl group at C-38. Analyses of shellfish extracts revealed that PTX-12 accumulated in Norwegian blue mussels (Mytilus edulis) and cockles (Cerastoderma edule), along with PTX-12 seco acids occurring as a complex mixture of diastereoisomers. LC-MS analysis of algal cells picked from the net haul from Fldevigen revealed that PTX-12 predominated in D. acuta and D. norvegica, whereas PTX-2 was the predominant pectenotoxin in D. acuminata. Preliminary observations indicate that the relative contents of PTX-2 and PTX-12 vary between sites and years in Norway, even within a single species of Dinophysis. Our data also suggest that heterotrophic dinoflagellates may accumulate toxins from their prey.
Publication date
PublisherACS Publications
Copyright notice© 2004 American Chemical Society
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada; Measurement Science and Standards
Peer reviewedYes
NRC number1695
NPARC number3538169
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Record identifierd7fd987e-fcb9-47a4-a272-d1427c0affeb
Record created2009-03-01
Record modified2016-05-09
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