Substance P primes lipoteichoic acid- and Pam3CysSerLys4- mediated activation of human mast cells by up-regulating Toll-like receptor 2

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DOIResolve DOI: http://doi.org/10.1111/j.1365-2567.2010.03296.x
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TypeArticle
Journal titleImmunology
Volume131
Issue2
Pages220230; # of pages: 11
Subjectchemokines; immunoglobulin E; mast cells; neuropeptides; substance P; vasoactive intestinal peptide
AbstractSubstance P (SP) is a neuropeptide with neuroimmunoregulatory activity that may play a role in susceptibility to infection. Human mast cells which are important in innate immune responses, were analysed for their responses to pathogen-associated molecules via Toll-like receptors (TLRs in the presence of SP. Human cultured mast cells (LAD2) were activated by SP and TLR ligands including lipopolysaccharide (LPS), Pam3CysSer- Lys4 (Pam3CSK4) and lipoteichoic acid (LTA), and mast cell leukotriene and chemokine production was assessed by enzyme-linked immunosorbent assay (ELISA) and gene expression by quantitative PCR (qPCR).
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LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedYes
NPARC number17326690
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Record identifierd96b6a23-eab8-424e-95e2-261355ff706a
Record created2011-03-18
Record modified2016-05-09
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