Multi-gene biomarker panel for reference free prostate cancer diagnosis : determination and independent validation

Download
  1. (PDF, 1 MB)
  2. Get@NRC: Multi-gene biomarker panel for reference free prostate cancer diagnosis : determination and independent validation (Opens in a new window)
DOIResolve DOI: http://doi.org/10.3109/1354750X.2010.511268
AuthorSearch for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleBiomarkers
Volume15
Issue8
Pages693706; # of pages: 14
SubjectProstate cancer; Molecular diagnostic; Gene expression microarray analysis; Data analysis; Biomarker discovery
AbstractIdentification of biomarkers that can accurately and reliably diagnose prostate cancer is clinically highly desirable. A novel classification method, K-closest resemblance was applied to several high-quality transcriptomic datasets of prostate cancer leading to the discovery of a panel of eight gene biomarkers that can detect prostate cancer with over 96% specificity and sensitivity in leave-one-out cross-validation. Independent validation on clinical samples confirmed the discriminatory power of this gene panel, yielding over 95% accuracy of diagnosis based on receiver-operating characteristic curve analyses. Different levels of validation of the proposed biomarker panel have shown that it allows extremely accurate diagnosis of prostate cancer. Application of this panel can possibly add a fast and objective tool to the pathologist’s arsenal following further clinical testing.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Information Technology
Peer reviewedYes
NPARC number16335062
Export citationExport as RIS
Report a correctionReport a correction
Record identifierda00e035-3ed2-41d3-b334-2cc1aee233d0
Record created2010-11-10
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)
Date modified: