Activity-based profiling of the proteasome pathway during hepatitis C virus infection

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DOIResolve DOI: http://doi.org/10.1002/pmic.201500169
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TypeArticle
Journal titleProteomics
ISSN1615-9853
Volume15
Issue22
Pages38153825; # of pages: 11
Subjectproteasome; ubiquitin; virus protein; chronic hepatitis C; controlled study; down regulation; Hepatitis C virus; protein expression; protein subunit; quantitative analysis; virus replication
AbstractHepatitis C virus (HCV) infection often leads to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The stability of the HCV proteins is controlled by ubiquitin-dependent and ubiquitin-independent proteasome pathways. Many viruses modulate proteasome function for their propagation. To examine the interrelationship between HCV and the proteasome pathways we employed a quantitative activity-based protein profiling method. Using this approach we were able to quantify the changes in the activity of several proteasome subunits and found that proteasome activity is drastically reduced by HCV replication. The results imply a link between the direct downregulation of the activity of this pathway and chronic HCV infection.
Publication date
PublisherWiley
LanguageEnglish
AffiliationNational Research Council Canada; Medical Devices
Peer reviewedYes
NPARC number21277371
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Record identifierda43b367-fe63-43ea-9274-105f77de416e
Record created2016-03-09
Record modified2016-05-09
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