Concentration-independent spontaneously forming biomimetric vesicles

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DOIResolve DOI: http://doi.org/10.1103/PhysRevLett.91.158105
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TypeArticle
Journal titlePhysical Review Letters
Volume91
Article number158105
AbstractIn this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge -1) or the divalent cation, calcium (Ca2+), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.
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AffiliationNational Research Council Canada; NRC Canadian Neutron Beam Centre
Peer reviewedNo
NPARC number12328825
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Record identifierda7a5c28-6b1e-41dd-8837-b4bde4f97e58
Record created2009-09-10
Record modified2016-05-09
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