Effect of cholesterol on structural and dynamic properties of tripalmitoyl glyceride. A high-pressure infrared spectroscopic study

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DOIResolve DOI: http://doi.org/10.1016/S0006-3495(89)82730-4
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TypeArticle
Journal titleBiophysical Journal
ISSN0006-3495
Volume56
Issue5
Pages845850
AbstractThe infrared spectra of tripalmitoyl glyceride confirm the tuning fork configuration previously attributed to trilauroyl glyceride (Small, D. M. 1986. Handbook of Lipid Research. Vol. 4). The acyl chains in solid tripalmitoyl glycerol, either within each molecule or between neighboring molecules, are oriented parallel to each other with the sn-3 acyl chains extended toward the opposite direction of the sn-1 and sn-2 chains. The presence of cholesterol increases the orientational disorder of the tripalmitoyl glyceride molecules in terms of increased reorientational fluctuations and twisting/torsion motions of the acyl chains. In the solid mixture, cholesterol is embedded in the tripalmitoyl glyceride lattice which results in a reorientation of the acyl chains within each molecule from a parallel packing to a nonparallel packing. No evidence was found for hydrogen bond formation between the OH group of cholesterol and any of the three C = O groups of tripalmitoyl glyceride.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedYes
NPARC number23001621
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Record identifierdadb99e3-f47f-496e-9f94-6b634a819eae
Record created2017-03-13
Record modified2017-03-13
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