Partial area of cholesterol in monounsaturated diacylphosphatidylcholine bilayers

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DOIResolve DOI: http://doi.org/10.1016/j.chemphyslip.2010.08.002
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TypeArticle
Journal titleChemistry and Physics of Lipids
Volume163
Issue8
Pages765770; # of pages: 6
SubjectPhosphatidylcholine bilayer; Cholesterol; SANS; Bilayer thickness; Partial area
AbstractThe influence of cholesterol on the structural parameters of phosphatidylcholine bilayers is studied by small-angle neutron scattering on unilamellar liposomes. Monounsaturated diacylphosphatidylcholines diCn:1PC with the length of acyl chains n = 14, 18 and 22 carbons are used. We confirm that the bilayer thickness increases with increasing concentration of cholesterol for all studied diCn:1PCs. However, partial areas per diCn:1PC and cholesterol molecule on lipid–water interface are found not to depend of cholesterol concentration. The partial area per cholesterol molecule is 0.24nm2. In addition, the partial area per diC18:1PC is larger than that for diC14:1PC and diC22:1PC
Publication date
LanguageEnglish
AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number16987301
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Record identifierdb4d6aa9-bad0-44b9-a71e-f1e0a9fd2a85
Record created2011-03-08
Record modified2016-05-09
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