Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging

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DOIResolve DOI: http://doi.org/10.1186/2045-8118-10-13
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TypeArticle
Journal titleFluids and barriers of the CNS
Volume10
Issue13
SubjectAlzheimer’s disease; Aβ peptides; Blood-brain barrier; Mdr-1a/b P-glycoprotein; Abcb1a/b; Abcg2; Optical imaging
AbstractAβ transport (flux) across the blood-brain barrier (BBB) is thought to contribute to the pathogenesis of Alzheimer’s disease as well as to elimination of toxic amyloid from the brain by immunotherapy. Several BBB transporters have been implicated in Aβ exchange between brain parenchyma and the circulation, including efflux transporters P-glycoprotein/ABCB1 and BCRP/ABCG2. Here we describe an application of in vivo optical imaging methods to study Aβ transport across the BBB in wild-type or animals deficient in specific efflux transporters.
Publication date
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NPARC number21275157
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Record identifierdd0cc51f-e0c0-4229-a391-d9e21230380f
Record created2015-05-21
Record modified2016-05-09
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