Stability of pressure-extruded liposomes made from archaeobacterial ether lipids

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DOIResolve DOI: http://doi.org/10.1007/BF00902745
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TypeArticle
Journal titleApplied Microbiology and Biotechnology
Volume42
Issue2-3
Pages375384; # of pages: 10
AbstractEther lipids were obtained from a wide range of archaeobacteria grown at extremes of pH, temperature, and salt concentration. With the exception ofSulfolobus acidocaldarius, unilamellar and/or multilamellar liposomes could be prepared from emulsions of total polar lipid extracts by pressure extrusion through filters of various pore sizes. Dynamic light scattering, and electron microscopy revealed homogeneous liposome populations with sizes varying from 40 to 230 nm, depending on both the lipid source and the pore size of the filters. Leakage rates of entrapped fluorescent or radioactive compounds established that those archaeobacterial liposomes that contained tetraether lipids were the most stable to high temperatures, alkaline pH, and serum proteins. Most ether liposomes were stable to phospholipase A2, phospholipase B and pancreatic lipase. These properties of archaeobacterial liposomes make them attractive for applications in biotechnology.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biological Sciences
Peer reviewedNo
NRC numberCHOQUET1994B
37391
NPARC number9382920
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Record identifierdd983f9f-b5f1-4ad1-92d1-8b76f1976c82
Record created2009-07-10
Record modified2016-05-09
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