A new tool to assess ceramide bioactivity: 6-bromo-7-hydroxycoumarinyl-caged ceramide

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DOIResolve DOI: http://doi.org/10.1039/C1CC12345A
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TypeArticle
Journal titleChemical Communications
Volume47
Issue32
Pages92369238; # of pages: 3
AbstractThe bioactivity of natural, long-chain ceramides has until now been studied after its delivery to cells in organic solvent mixtures containing dodecane. We have synthesized ceramides conjugated to a (6-bromo-7-hydroxycoumarin-4-yl)methyl group. The photocaged ceramide is efficiently released with 350 nm light in aqueous solution at neutral pH, thus providing a promising new tool to study ceramide's properties.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; NRC Steacie Institute for Molecular Sciences; National Research Council Canada
Peer reviewedYes
NPARC number19649703
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Record identifierdd9cd129-0ebd-4fb8-ae89-c54392e657f8
Record created2012-03-28
Record modified2016-05-09
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