Degradation and drug release in calcium polyphosphate bioceramics: An MRI-based characterization

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DOIResolve DOI: http://doi.org/10.1016/j.actbio.2012.05.026
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TypeArticle
Journal titleActa Biomaterialia
ISSN1742-7061
Volume8
Issue10
Pages38213831; # of pages: 11
SubjectMagnetic resonance imaging; Controlled release; Calcium polyphosphate; Bioceramics
AbstractDegradable, bioceramic bone implants made of calcium polyphosphate (CPP) hold potential for controlled release of therapeutic agents in the treatment of localized bone disease. Magnetic resonance imaging techniques for non-invasively mapping fluid distribution, T1 and T2 relaxation times and the apparent diffusion coefficient were performed in conjunction with a drug elution protocol to resolve free and bound water components within the material microstructure in two CPP formulations (G1 and G2). The T2 maps provided the most accurate estimates of free and bound water, and showed that G1 disks contained a detectable free water component at all times, with drug release dominated by a Fickian diffusion mechanism. Drug release from G2 disks was characterized by a combined diffusional/structural relaxation mechanism, which may be related to the gradual infiltration of a free water component associated with swelling and/or chemical degradation.
Publication date
LanguageEnglish
AffiliationMedical Devices; National Research Council Canada
Peer reviewedYes
IdentifierS1742706112002395
NPARC number21268660
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Record identifierde0497eb-c7be-4bc3-b3be-8d589d7d6ea9
Record created2013-11-06
Record modified2016-05-09
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