Competition between immune function and lipid transport for the protein apolipophorin III leads to stress-induced immunosuppression in crickets

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DOIResolve DOI: http://doi.org/10.1242/jeb.013136
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TypeArticle
Journal titleJournal of Experimental Biology
Volume211
Issue4
Pages531538; # of pages: 8
AbstractIntense physical activity results in transient immunosuppression in a wide range of animals. We tested the hypothesis that competition between immune function and lipid transport for the protein apolipophorin III (apoLpIII) can cause transient immunosuppression in crickets. Both flying, an energetically demanding behavior, and an immune challenge reduced the amount of monomeric (free) apoLpIII in the hemolymph of crickets. Because both immune function and flying depleted free apoLpIII, these two phenomena could be in competition for this protein. We showed that immune function was sensitive to the amount of free apoLpIII in the hemolymph. Reducing the amount of free apoLpIII in the hemolymph using adipokinetic hormone produced immunosuppression. Increasing apoLpIII levels after flight by pre-loading animals with trehalose reduced immunosuppression. Increasing post-flight apoLpIII levels by injecting purified apoLpIII also reduced flight-induced immunosuppression. These results show that competition between lipid transport and immune function for the same protein can produce transient immunosuppression after flight-or-fight behavior. Intertwined physiological systems can produce unexpected trade-offs.
Publication date
PublisherThe Company of Biologists
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Marine Biosciences; Industrial Research Assistance Program
Peer reviewedYes
NRC number42754
1717
NPARC number3538078
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Record identifierdef53014-168d-4031-95de-c545f040a983
Record created2009-03-01
Record modified2016-05-09
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