The synthesis and self-assembly studies of two bioactive BMP-7 short peptides modified rosette nanotubes for bone tissue engineering

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DOIResolve DOI: http://doi.org/10.1557/opl.2011.522
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TypeArticle
Proceedings titleSymposium QQ – Nanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II
Series titleMaterials Research Society Symposium Proceedings
Conference2010 MRS Fall Meeting, 29 November 2010 through 3 December 2010, Boston, MA
ISSN0272-9172
ISBN9781618395207
Volume1316
Pages8085; # of pages: 6
SubjectBone fracture; Biomaterials; Nanostructures; Self assembly; Tissue engineering
AbstractBone fractures are one of the most common bone complications. In more severe cases, bone fixation is accomplished using titanium (Ti) implant materials. Unfortunately, the need for revision surgery often arises due to implant loosening and/or deterioration of the implant/bone interface. Rosette nanotubes (RNTs) are a class of self-assembled organic materials obtained through the self-assembly of a guanine-cytosine hybrid base (G∧C motif). These organic materials have been found to increase osteoblast (bone forming cells) adhesion and hydroxyapatite deposition (bone regeneration) on titanium implants as well as on engineered hydrogels. In order to increase the bioactivity of RNTs to enhance bone cell function on Ti implants, two RNT motifs functionalized with different bioactive deca-peptides (A, B) chosen from the knuckle region of bone morphogenic proteins-7 (BMP-7) were synthesized. Their self-assembly process was investigated in water using UV-Vis and SEM techniques. © 2011 Materials Research Society.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); National Institute for Nanotechnology
Peer reviewedYes
NPARC number21272046
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Record identifiere01e15c0-6688-4e8e-9441-5da781cebe9a
Record created2014-05-23
Record modified2016-05-09
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