Ethanol extract of Liuwei Dihuang reduces weight gain and visceral fat in obese-prone CD rats fed a high-fat diet

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DOIResolve DOI: http://doi.org/10.1177/1535370214525313
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TypeArticle
Journal titleExperimental Biology and Medicine
ISSN1535-3699
Volume239
Issue5
Pages552558; # of pages: 7
Subjectblood lipids; energy expenditure; hormones; Liuwei Dihuang ethanol extract; obese rats; visceral fat; weight gain
AbstractThe current study investigated the effect and mechanisms of action of Liuwei Dihuang ethanol extract (LWDH-EE) on obesity and related metabolic phenotypes in male obese-prone CD rats. The rats were fed a high-fat diet and treated with 0 (obese control), 350 (EE350), or 700 (EE700) mg/kg/d of LWDH-EE in water once a day by gavage feeding for 10 weeks. The EE700 decreased body weight after 3 weeks of the treatment and the effect was maintained throughout the remaining study period. The EE700 also significantly reduced visceral fat and improved metabolic phenotypes by lowering the serum total cholesterol (T-C), non-high-density lipoprotein cholesterol, triacylglycerol, free fatty acids (FFA), and leptin levels. The EE350 reduced epididymal fat, serum T-C, and FFA but did not significantly affect other parameters. LWDH-EE dose-dependently increased fat and carbohydrate oxidations, energy expenditure, and the relative efficiency of fat oxidation for energy expenditure. EE350 and EE700 reduced food intake only in week 5 and did not affect the accumulative food intake in every week and the entire treatment period. Taken together, the results suggest that LWDH-EE is a potential therapeutic agent for the prevention of obesity possibly through a primary action of increasing energy metabolism and expenditure, along with a possible effect of decreasing energy intake.
Publication date
LanguageEnglish
AffiliationAquatic and Crop Resource Development; National Research Council Canada
Peer reviewedYes
NRC numberNRC-ACRD-55985
NPARC number21272278
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Record identifiere029b96e-cf85-40e0-bf59-40091d0c8162
Record created2014-07-23
Record modified2016-05-09
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