Effects of neoplastic transformation and teniposide (VM26) on protein kinase C isoform expression in rodent fibroblasts

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DOIResolve DOI: http://doi.org/10.1016/S0304-3835(99)00417-6
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TypeArticle
Journal titleCancer Letters
ISSN0304-3835
Volume153
Issue1-2
Pages1323
Subjectmiddle T antigen; cell death; protein kinase C expression; proteolysis; F111; NIH3T3
AbstractThis study examined changes in protein kinase C (PKC) isoforms in rodent fibroblasts (rat F111 and mouse NIH3T3), transformed by the polyoma virus middle T antigen (mT) and undergoing apoptosis in response to teniposide (VM26). The mT-transformed cells up-regulated PKC δ and down-regulated both PKC ε and PKC λ expression, and were more sensitive to the drug than their non-transformed counterparts. The drug treatment further lowered the expression of PKC ε, triggered nuclear translocation of PKC δ and its site-specific proteolysis, consistent with the notion that changes in specific PKC isoforms play a role not only in the neoplastic transformation of fibroblasts, but also in their apoptotic response.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number23001311
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Record identifiere078849d-889f-4768-b286-356463d99adb
Record created2017-01-17
Record modified2017-01-17
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