Toward high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age

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DOIResolve DOI: http://doi.org/10.1016/S1074-5521(02)00105-9
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TypeArticle
Journal titleChemistry & Biology
Volume9
Issue2
Pages145156; # of pages: 12
AbstractIn the age of high-throughput biology, novel genes and proteins are emerging quickly. the need for developing organic synthesis-derived methods that allow rapid access to polyfunctional, complex natural product-like compounds is growing constantly, largely because these small-molecule-based compounds serve as smart, powerful tools both in understanding the roles and functions of emerging biological targets and in validating their biological responses. Developing asymmetric synthesis-derived organic reactions on solid phase allows the sythesis of complex natural product-like compounds in a high-throughput manner. Solid phase organic sythesis is now commonly utilized in the library synthesis of rather simple compounds (i.e., compounds with no multiple stereogenic centers). With few exceptions, the sythesis of complex natural product-like derivatives is still in its infancy. Some recent efforts made in this area indicate opportunities yet to be explored.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12327084
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Record identifiere0d62634-7a53-4522-9d9a-b396b7140077
Record created2009-09-10
Record modified2016-05-09
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