Studies of a viral suppressor of RNA silencing p19-CFP fusion protein: A FRET-based probe for sensing double stranded fluorophore tagged small RNAs

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DOIResolve DOI: http://doi.org/10.1016/j.bpc.2009.05.001
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TypeArticle
Journal titleBiophysical Chemistry
Volume143
Issue3
Pages166169; # of pages: 3
SubjectRNA silencing; Carnation Italian ringspot virus; Chemical probes; RNA–protein interactions; FRET
AbstractEukaryotes have evolved complex cellular responses to double-stranded RNA. One response that is highly conserved across many species is the RNA silencing pathway. Tombusviruses have evolved a mechanism to evade the RNA silencing pathway that involves a small protein, p19, that acts as a suppressor of RNA silencing. This protein binds specifically to small-interfering RNAs (siRNAs) with nanomolar affinity in a sequence-independent manner and with size selectivity.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Steacie Institute for Molecular Sciences
Peer reviewedYes
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This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number16080398
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Record identifiere17757e2-9099-4122-b3dc-2621c18fb8a0
Record created2010-09-21
Record modified2016-05-09
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