Low thrombogenicity coating of nonwoven PET fiber structures for vascular grafts

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DOIResolve DOI: http://doi.org/10.1002/mabi.201000390
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TypeArticle
Journal titleMacromolecular Bioscience
Volume11
Issue4
Pages493502; # of pages: 10
AbstractVascular PET grafts (Dacron) have shown good performance in large vessels (≥6mm) applications. To address the urgent unmet need for small-diameter (2–6mm) vascular grafts, proprietary high-compliance nonwoven PET fiber structures were modified with various PEG concentrations using PVA as a cross-linking agent, to fabricate non-thrombogenicmechanically compliant vascular grafts. The blood compatibility assays measured through platelet adhesion (SEM and mepacrine dye) and platelet activation (morphological changes, P-selectin secretion, and TXB2 production) demonstrate that functionalization using a 10% PEG solution was sufficient to significantly reduce platelet adhesion/activation close to optimal literature-reported levels observed on carbon-coated ePTFE.
Publication date
LanguageEnglish
AffiliationNRC Industrial Materials Institute; NRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NRC number53825
NPARC number18370421
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Record identifiere1c5bdba-06ee-4e99-9f88-82cbea296866
Record created2011-08-03
Record modified2017-03-23
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