Cu2+-labeled, SPION loaded porous silica nonparticles for cell labeling and multifunctional imaging probes

Download
  1. (PDF, 389 KB)
  2. Get@NRC: Cu2+-labeled, SPION loaded porous silica nonparticles for cell labeling and multifunctional imaging probes (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.biomaterials.2009.12.025
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleBiomaterials
Volume31
Issue10
Pages28662873; # of pages: 8
SubjectCell viability; Copper; Cytotoxicity; In vitro test; MRI (magnetic resonance imaging); Surface modification
AbstractWe have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell tracking with magnetic resonance (MR) imaging and positron emission tomography (PET). Herein we report the synthesis, surface functionalization and characterization of the magnetic nanoparticle-based probes and evaluate their cell-labeling efficacy, cytoxicity and relaxivity in comparison to one of the most commonly utilized MRI contrast agents, Feridex®.
Publication date
LanguageEnglish
AffiliationNRC Steacie Institute for Molecular Sciences; NRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number17653072
Export citationExport as RIS
Report a correctionReport a correction
Record identifiere1d02677-8763-4868-b90f-654c34307172
Record created2011-04-01
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)