Prognosis of chronic lymphocytic leukemia from infrared spectra of lymphocytes

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DOIResolve DOI: http://doi.org/10.1016/S0022-2860(96)09462-8
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TypeArticle
Journal titleJournal of Molecular Structure
Volume408-409
Pages253256; # of pages: 4
SubjectChronic lymphocytic leukemia; Infrared spectroscopy; Linear discriminant analysis; DNA spectra
AbstractPeripheral mononuclear cells obtained from blood of normal individuals and from patients with chronic lymphocytic leukemia (CLL) were investigated by infrared spectroscopy and multivariate statistical analysis. Not only are the spectra of CLL cells different from those of normal cells, but hierarchical clustering also separated the CLL cells into a number of subclusters, based on their different DNA content, a fact which may provide a useful diagnostic tool for staging (progression of the disease) and multiple clone detection. Moreover, there is evidence for a correlation between the increased amount of DNA in the CLL cells and the in-vivo doubling time of the lymphocytes in a given patient.
Publication date
PublisherElsevier
Copyright noticeYou may reproduce (print, make photocopies, or download) materials from NPArC without permission for non-commercial purposes (research, education, and private study), on the condition that you provide proper attribution of the sources in all copies.
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biodiagnostics
Access conditionavailable
unlimited
public
Peer reviewedYes
NPARC number9201850
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Record identifiere1e75503-4c29-43d2-a09a-c63bc762fcce
Record created2009-10-03
Record modified2016-10-28
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