Formation mechanism of self-assembled unilamellar vesicles

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Journal titleCanadian Journal of Physics
Pages735740; # of pages: 6
AbstractUniform size self-assembled unilamellar vesicles (ULVs) can be produced from mixtures of weakly charged short- and long-chain phospholipids. These lipid mixtures self-assemble into bilayered micelles (so-called bicelles), and a bicelle to ULV transition has been previously reported. Here, we discuss the effect of various parameters (i.e., lipid concentration, charge density, membrane rigidity, lipid composition, and lipid hydrocarbon chain length) on ULV radius as determined by small angle neutron scattering (SANS). SANS data were best fit using a core-shell disk and a spherical-shell model to obtain the size of bicelles and ULVs, respectively. From the present experiments we conclude that a previously proposed mechanism of ULV formation, where bicelles coalesce into large precursor and self-fold into ULVs, is able to explain the present SANS data.
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AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number16983750
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Record identifiere388280b-688c-4199-a5d2-f3480cf6d0de
Record created2011-03-08
Record modified2016-05-09
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