Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet

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DOIResolve DOI: http://doi.org/10.1016/j.jff.2013.05.007
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TypeArticle
Journal titleJournal of Functional Foods
ISSN1756-4646
Volume5
Issue3
Pages13921401; # of pages: 10
SubjectRattus
AbstractThis study was designed to evaluate a polyphenols-rich fruit-based functional beverage on blood pressure, serum and liver lipid profiles in vivo. Sixty spontaneously hypertensive rats were divided into five groups and were fed with a AIN-93G-diet as the normal control (NC), high cholesterol diet as atherogenic control (AC), and the AC diet with three different beverage dosages (0.5. X, 1. X, 2. X), where X is the equivalence of two portion sizes for an adult (X = 10. mL/kg. BW/day) after dose translation. Blood pressure was measured during weeks 2 and 4 using a tail-cuff method. Systolic blood pressures were lowered by the beverage at the supplementation of 1. X/2. X after 2. week but not after 4. week. The oral administration of the beverage at 1. X/2. X significantly lowered liver cholesterol and total and non-HDL-cholesterol levels in the serum. Thus, the newly formulated beverage possessed hypolipidaemic effects while showing inconsistent effect in lowering the blood pressure. © 2013 The Authors.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Aquatic and Crop Resource Development (ACRD-DCRA)
Peer reviewedYes
NPARC number21269647
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Record identifiere3955531-08fa-493f-9990-c1020d8fe56f
Record created2013-12-13
Record modified2016-05-09
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