Identification and quantification of Cyclolinopeptides in five flaxseed cultivars

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DOIResolve DOI: http://doi.org/10.1021/jf301847u
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TypeArticle
Journal titleJournal of Agricultural and Food Chemistry
ISSN0021-8561
1520-5118
Volume60
Issue35
Pages85718579; # of pages: 9
Subjectcyclolinopeptide; HPLC quantification; flaxseed cultivars; environment interaction
AbstractCyclolinopeptides are a group of naturally occurring hydrophobic cyclic peptides found in flaxseed and flax oil that have immunosuppressive activity. This study describes the measurement of flaxseed cyclolinopeptide concentrations using an internal standard HPLC method. In addition, the concentration of cyclolinopeptides in the seed of Canadian flax cultivars grown at two locations over two years is reported. The data are consistent with the formation of flaxseed cyclolinopeptides from two ribosome-derived precursors. Each precursor protein includes the sequences corresponding to three cyclolinopeptides from which those cyclolinopeptides are presumably derived by precursor processing. The concentrations of cyclolinopeptides C and E, which are encoded by the same gene sequence, are highly correlated, and the concentrations of cyclolinopeptides D, F, and G, which are encoded by a second gene sequence, are also highly correlated. The strong correlation between the cyclolinopeptides arising from the same gene may prove to be important in understanding how peptide concentration is controlled. Additional research may lead to approaches to improve flax either as a platform for peptide production or as a source of oil with improved drying properties and flavor.
Publication date
PublisherACS Publications
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NRC number55446
NPARC number21268517
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Record identifiere5a7d140-a70d-4a73-8fbe-e0eaa752dcac
Record created2013-09-09
Record modified2016-05-09
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