Infrared spectroscopy : shedding light on synovitis in patients with rheumatoid arthritis

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DOIResolve DOI: http://doi.org/10.1093/rheumatology/keg034
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TypeArticle
Journal titleRheumatology
ISSN1462-0324
1462-0332
Volume42
Issue1
Pages7682; # of pages: 7
SubjectRheumatoid arthritis; Early synovitis; Near infrared spectroscopy; Multivariate pattern recognition
AbstractObjectives: It is difficult to determine the extent of synovial involvement early in the course of rheumatoid arthritis. A spectroscopic technique was used to characterize the synovium of the small finger joints in both early and late rheumatoid arthritis. This synovium was also compared against normal joints. Methods: Near-infrared spectroscopy assesses the absorption of near-infrared light by specific joints, giving a characteristic ‘fingerprint’ of the properties of the underlying tissues. Triple measurements by infrared spectroscopy were taken at the bilateral second and third metacarpophalangeal joints. Multivariate analysis was applied. Results: Analysis was able to demonstrate relationships between the specific sources of spectral variation and joint tenderness or swelling as well as radiographic damage. Further use of multivariate analysis allowed recognition of the spectral patterns seen in early disease vs late rheumatoid arthritis and correct classification of over 74% of the joints. Conclusions: The spectral regions where differences occurred were in the absorption bands related to tissue oxygenation status, allowing the provocative implication that this technique could be detecting ischaemic changes within the joint. Near-infrared spectroscopy may thus be able to provide us with some information about the biochemical changes associated with synovitis.
Publication date
PublisherBritish Society for Rheumatology
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NRC number1967
NPARC number9148444
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Record identifiere6e95319-7e88-4880-b842-ce93eb42c27a
Record created2009-06-25
Record modified2016-08-16
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