Simon metabolites of α-tocopherol are not formed via a rate-controlling scission of the 3′C-H bond

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DOIResolve DOI: http://doi.org/10.1016/0891-5849(90)90021-A
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TypeArticle
Journal titleFree Radical Biology and Medicine
ISSN0891-5849
Volume9
Issue5
Pages435439; # of pages: 5
Subjectalpha tocopherol; deuterium; adrenal gland; animal tissue; article; brain cortex; drug metabolism; gas chromatography; isotope labeling; kidney; liver; male; mass spectrometry; nonhuman; oral drug administration; priority journal; rat; Animal; Free Radicals; Kinetics; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Vitamin E; Animalia
AbstractThe major in vivo oxidation products of α-tocopherol, α-T, are the Simon metabolites, 1 and 2. For these compounds to be formed from α-T the polyisoprenoid tail of α-T must be oxidatively cleaved at the 3′ carbon atom. Comparison of the levels of 2R,4′R,8′R-α-(3′,3′-2H2)-T and 2R,4′R,8′R-α-[5,7-(C2H3)2-T remaining in various tissues of rats which had been preloaded with equal quantities of these two forms of vitamin E following a change to a vitamin E-free diet has shown that there is no statistically significant difference in the rates of loss of these two deuterium-labeled α-T's. This demonstrates that the Simon metabolites are not formed by a rate-controlling scission of the 3′-C-H bond of α-T. © 1990.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Steacie Institute for Molecular Sciences (SIMS-ISSM)
Peer reviewedYes
NPARC number21276787
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Record identifiere7465945-ae39-49c5-98fd-e1f4230a3300
Record created2015-10-13
Record modified2016-05-09
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