Influence of water activity on the enantioselective esterification of (R,S)-ibuprofen by crosslinked crystals of <I>Candida antarctica</I> lipase B in organic solvent media

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DOIResolve DOI: http://doi.org/10.1002/bit.10051
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TypeArticle
Journal titleBiotechnology and Bioengineering
Volume75
Issue5
Pages559562; # of pages: 4
AbstractThe lipase B from was purified from a commercial source and crystalized. The microcrystals were crosslinked using glutaraldehyde. The crosslinked crystals were then used to catalyze the esterification of ()-ibuprofen with dodecanol in octane at various water activities. As for the commercial preparation immobilized on acrylic resin, Novozym 435, low water activities foster better enantioselectivity, and the maximum reaction rates are obtained for W = 0.1. � 2001 John Wiley & Sons, Inc. Biotechnol Bioeng 75: 559-562, 2001.
Publication date
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NPARC number12327007
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Record identifiere8be2d6d-d02b-403c-8e90-c0631d6890fa
Record created2009-09-10
Record modified2016-05-09
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