Laser desorption/ionization mass spectrometry using tunable nanoporous structures

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TypeArticle
Proceedings title15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, October 2-6, 2011, Seattle, WA, USA
ISBN9781618395955
Volume1
Pages592594; # of pages: 3
SubjectBackground signals; Desorption/ionization; GLAD; Laser desorption/ionization; Laser desorption/ionization mass spectrometries; Matrix assisted laser desorption/ionization; Nanoporous structures; Porous thin films; Mass spectrometry; Peptides; Porous silicon; Thin films; Desorption
AbstractThe performance of porous silicon and cobalt glancing angle deposited (GLAD) thin films for matrix-free laser desorption/ionization-MS analysis of carbohydrates, peptides and drugs with molecular weights < 2,500 Dalton is presented. The performance of these films for selected peptides and small drugs detection is similar to the best reported for desorption/ionization on electrochemically etched porous silicon with detection limits in the femtomole to sub-femtomole range, and was superior to matrix-assisted laser desorption/ionization (MALDI)-MS in terms of background signal and spot-to-spot reproducibility. Copyright © (2011) by the Chemical and Biological Microsystems Society.
Publication date
Linkhttp://www.rsc.org/images/LOC/2011/PDFs/Papers/199_0885.pdf
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); National Institute for Nanotechnology
Peer reviewedYes
NPARC number21271975
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Record identifiere9f4d402-a341-4747-81f5-0920ba013009
Record created2014-05-14
Record modified2016-05-09
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