Analyzing protein-protein interactions in cell membranes

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Journal titleBioEssays
Pages196203; # of pages: 8
AbstractInteractions among membrane proteins regulate numerous cellular processes, including cell growth, cell differentiation and apoptosis. We need to understand which proteins interact, where they interact and to which extent they interact. This article describes a set of novel approaches to measure, on the surface of living cells, the number of clusters of proteins, the number of proteins per cluster, the number of clusters or membrane domains that contain pairs of interacting proteins and the fraction of one protein species that interacts with another protein within these domains. These data can then be interpreted in terms of the function of the protein-protein interactions.
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AffiliationNational Research Council Canada
Peer reviewedNo
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number12327082
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Record identifierea8191b1-bbaf-4d65-b91f-0238aec78151
Record created2009-09-10
Record modified2016-05-09
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