An antiproliferative norditerpene dilactone, Nagilactone C, from Podocarpus neriifolius

Download
  1. Get@NRC: An antiproliferative norditerpene dilactone, Nagilactone C, from Podocarpus neriifolius (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1078/S0944-7113(04)70071-9
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titlePhytomedicine
ISSN0944-7113
Volume8
Issue6
Pages489491; # of pages: 3
SubjectPodocarpus neriifolius; antiproliferative activity for cancer cells; norditerpene dilactone; nagilactone C
AbstractAn ethanolic extract of Podocarpus neriifolius D. Don (Podocarpaceae) showed antiproliferative activity against two major tumor cell lines, viz. human HT-1080 fibrosarcoma and murine color 26-L5 carcinoma. Bioassay guided fractionation showed the highest antiproliferative activity in chloroform–soluble fraction. Nagilactone C, the major constituent of this fraction was isolated and characterized by using NMR, IR and FAB-MS spectroscopic methods. Nagilactone C possessed potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 μg/ml, respectively. Hence, nagilactone C could be the active constituent present in this plant.
Publication date
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274802
Export citationExport as RIS
Report a correctionReport a correction
Record identifiereba13dac-1189-4cce-ae12-f5348e2fcd97
Record created2015-04-12
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)