Solution- and solid-phase synthesis of tetrahydroquinoline-based polycyclics having α,β -unsaturated γ-lactam and δ-lactone functionalities

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DOIResolve DOI: http://doi.org/10.1055/s-0029-1218576
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TypeArticle
Journal titleSynlett
Volume2010
Issue2
Pages199202; # of pages: 4
Subjectlactams; lactones; fused-ring systems; heterocycles; asymmetric synthesis; solid-phase synthesis
AbstractWith the goal of the library generation using the tetrahydroquinoline- based derivative, a simple and practical enantioselective synthesis of the tetrahydroquinoline derivatives having a,bunsaturated g-lactam and d-lactone functional groups was achieved. The phenolic hydroxy group in the a,b-unsaturated g-lactam was utilized as an anchoring site for the solid-phase synthesis. The ringclosing metathesis approach yielded the desired tricyclic products on the solid phase.
Publication date
LanguageEnglish
AffiliationNRC Steacie Institute for Molecular Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17673537
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Record identifierec9e57f4-c689-4ab9-a6eb-91e1458bc1ff
Record created2011-04-03
Record modified2016-05-09
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