Selective and sensitive electrochemical detection of glucose in neutral solution using platinum-lead alloy nanoparticle/carbon nanotube nanocomposites

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DOIResolve DOI: http://doi.org/10.1016/j.aca.2007.05.047
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TypeArticle
Journal titleAnalytica Chimica Acta
Volume594
Issue2
Pages175183; # of pages: 9
Subjectenv; Fructose; Glucose; Glucose detection; Platinum-lead nanoparticle; Carbon nanotube; Amperometry; Nafion; Interferences
AbstractElectrodeposition of Pt-Pb nanoparticles (PtPbNPs) to multi-walled carbon nanotubes (MWCNTs) resulted in a stable PtPbNP/MWCNT nanocomposite with high electrocatalytic activity to glucose oxidation in either neutral or alkaline medium. More importantly, the nanocomposite electrode with a slight modification exhibited high sensitivity, high selectivity, and low detection limit in amperometric glucose sensing at physiological neutral pH (poised at a negative potential). At +0.30V in neutral solution, the nanocomposite electrode exhibited linearity up to 11mM of glucose with a sensitivity of 17.8muAcm(-2)mM(-1) and a detection limit of 1.8muM (S/N=3). Electroactive ascorbic acid (0.1mM), uric acid (0.1mM) and fructose (0.3mM) invoked only 23%, 14% and 9%, respectively, of the current response obtained for 3mM glucose. At -0.15V in neutral solution, the electrode responded linearly to glucose up to 5mM with a detection limit of 0.16mM (S/N=3) and detection sensitivity of approximately 18muAcm(-2)mM(-1). At this negative potential, ascorbic acid, uric acid, and fructose were not electroactive, therefore, not interfering with glucose sensing. Modification of the nanocomposite electrode with Nafion coating followed by electrodeposition of a second layer of PtPbNPs on the Nafion coated PtPbNP/MWCNT nanocomposite produced a glucose sensor (poised at -0.15V) with a lower detection limit (7.0muM at S/N=3) and comparable sensitivity, selectivity and linearity compared to the PtPbNP/MWCNT nanocomposite. The Nafion coating lowered the detection limit by reducing the background noise, while the second layer of PtPbNPs restored the sensitivity to the level before Nafion coating.
Publication date
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number49056
NPARC number3539348
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Record identifieredf910b2-b959-4d0b-9bec-66928c39d93d
Record created2009-03-01
Record modified2016-05-09
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