Constitutive Modelling of Endothelium Denudation for Finite Element Simulation of Angioplasty

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Proceedings titleBiomedical Simulation. 4th International Symposium, ISBMS 2008, London, UK, July 7-8, 2008. Proceedings
Lecture notes in Computer Science
ConferenceInternational Symposium on Computational Models for Biomedical Simulation - ISBMS08, London, UK, July 7-8, 2008
Pages1927; # of pages: 9
Subjectangioplasty; restenosis; endothelium; stretch; friction; pressure
AbstractThis study aims at characterizing and modelling the effect of mechanical factors on endothelial denudation during angioplasty, such as normal force between balloon and artery, stretching of arterial walls, and relative displacement between contacting surfaces. Friction damage was applied to porcine aorta samples with different contact forces, relative displacements, and biplanar stretching conditions. After the tests, endothelium denudation was quantified by isolating and counting the remaining endothelial cells. Using multiple-regression analysis, a constitutive model is proposed for integration in finite element software. This model will help optimize balloon and stent deployment conditions to minimize the amount of damage to the endothelium, and eventually to reduce the occurrence of restenosis.
Publication date
AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute
Peer reviewedYes
NRC number50250
NPARC number18890171
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Record identifierf00fb9f1-6698-4454-942d-5fd81dd312f9
Record created2011-11-04
Record modified2016-05-09
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