Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells

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DOIResolve DOI: http://doi.org/10.1016/j.neulet.2011.01.055
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TypeArticle
Journal titleNeuroscience letters
Issue492
Pages7679; # of pages: 4
Subjectbaicalin; copper; Abeta; aggregation; hydrogen peroxide
AbstractAlzheimer’s disease (AD) is a common form of neurodegenerative disease. Mounting evidence suggests that metal ions play a key role in the aggregation of amyloid β peptide (Aβ), which acts as a factor or cofactor in the etiopathogenesis of AD. Therefore, inhibition of Aβ aggregation emerges as a potential approach for the treatment of AD. We have found that baicalin can interact with copper directly and inhibits Aβ 1–42 aggregation. In addition, baicalin protects SH-SY5Y cells from oxidative injuries induced by Aβ 1–42 aggregation through decreasing H2O2 production that is normally formed as a deleterious byproduct of beta amyloid aggregation and the formation of plaques. Taken together, these data indicate that baicalin may be a potential agent to inhibit Aβ aggregation and thereby delay, mitigate or modify the progression of neurodegenerative diseases such as AD.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Nutrisciences and Health
Peer reviewedYes
NPARC number17364189
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Record identifierf0955e6b-d4f3-439b-b385-ff7423ac411c
Record created2011-03-22
Record modified2016-05-09
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