Imaging of arterial plaque by quadrature swept-source optical coherence tomography with signal to noise ratio enhancements

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DOIResolve DOI: http://doi.org/10.4236/jbise.2011.412093
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TypeArticle
Journal titleJournal of Biomedical Science and Engineering
ISSN1937-6871
Volume4
Issue12
Pages755761; # of pages: 7
Subjectoptical coherence tomography; arterial plaque; medical and biological imaging; semiconductor optical amplifier
AbstractArterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using a signal to noise ratio enhanced swept-source optical coherence tomography system with a quadrature interferometer (QSS-OCT). A semiconductor optical amplifier is used in the sample arm to amplify the weak signal scattered from arterial plague. Signal to noise ratio improvement are demonstrated in our QSS-OCT system. This finding results into an increase of the penetration depth possible in OCT images, from 1 mm to 2 mm. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with our QSS-OCT system.
Publication date
LanguageEnglish
AffiliationNRC Institute for Microstructural Sciences; National Research Council Canada
Peer reviewedYes
NPARC number21275142
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Record identifierf0b1ad9a-9896-43ed-b0f3-9f9459dcc82b
Record created2015-05-12
Record modified2016-05-09
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