Differentiating atherosclerotic plaque burden in arterial tissues using femtosecond CARS-based multimodal nonlinear optical imaging

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DOIResolve DOI: http://doi.org/10.1364/BOE.1.000059
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TypeArticle
Journal titleBiomedical Optics Express
Volume1
Issue1
Pages5973; # of pages: 15
SubjectMedical&biological imaging; Optical diagnostics for medicine; Nonlinear microscopy; Spectroscopy, coherent anti-Stokes Raman scattering
AbstractA femtosecond CARS-based nonlinear optical microscope was used to simultaneously image extracellular structural proteins and lipid-rich structures within intact aortic tissue obtained from myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits (WHHLMI). Clear differences in the NLO microscopic images were observed between healthy arterial tissue and regions dominated by atherosclerotic lesions. In the current ex-vivo study, we present a single parameter based on intensity changes derived from multi-channel NLO image to classify plaque burden within the vessel. Using this parameter we were able to differentiate between healthy regions of the vessel and regions with plaque, as well as distinguish plaques relative to the age of the WHHLMI rabbit.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; NRC Steacie Institute for Molecular Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17620247
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Record identifierf0c490e2-4101-4443-a69d-f24b6decae31
Record created2011-04-03
Record modified2016-05-09
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