Engaging neuroscience to advance translational research in brain barrier biology

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DOIResolve DOI: http://doi.org/10.1038/nrn2995
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TypeArticle
Journal titleNature Reviews Neuroscience
Volume12
Issue3
Pages169182; # of pages: 14
Subjectblood–brain barrier; neuroscience; brain barrier sciences
AbstractThe delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood–brain barrier (BBB) and the blood–cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and — when barrier integrity is impaired — in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biological Sciences
Peer reviewedYes
NPARC number19739546
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Record identifierf1ad24d3-2a1b-43d4-877c-149ecee13aef
Record created2012-04-19
Record modified2016-05-09
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