Isotope scrambling and error magnification in multiple-spiking isotope dilution

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DOIResolve DOI: http://doi.org/10.1007/s00216-009-2619-x
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TypeArticle
Journal titleAnalytical and Bioanalytical Chemistry
ISSN1618-2642
1618-2650
Volume394
Issue1
Pages199205
Subjectisotope dilution; multiple spiking; uncertainty; error propagation; monte Carlo; isotope scrambling
AbstractThe purpose of performing multiple spiking isotope dilution is to quantify interconverting substances. This feature has been utilized in analytical chemistry now for more than a decade. In this manuscript we show that the interconversion of analytes is inevitably accompanied by the gradual loss of information that can be extracted from the isotope patterns. Therefore, any corrections for analyte interconversion are performed at the expense of the precision of the obtained amount of interconverting analytes. Consequently, there is a natural, predictable limit to the applicability of multiple-spiking isotope dilution methods that can be summarized into a simple equation.
Publication date
PublisherSpringer
LanguageEnglish
AffiliationNRC Institute for National Measurement Standards; National Research Council Canada
Peer reviewedYes
NPARC number23001628
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Record identifierf1e1136e-df46-479e-9368-d40c3efcae20
Record created2017-03-13
Record modified2017-03-13
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