A comparison of data analysis methods for determining gas phase stabilities by CID: Alkali metal complexes of polyether ionophore antibiotics

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DOIResolve DOI: http://doi.org/10.1016/j.jasms.2005.01.025
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TypeArticle
Journal titleJournal of the American Society of Mass Spectrometry
Volume16
Issue5
Pages779791; # of pages: 13
Subjectantibiotics; methods; mass spectrometry
AbstractThe gas phase stabilities of Group I metal complexes of the polyether ionophore antibiotics lasalocid and monensin were investigated by collision induced dissociation mass spectrometry. Electrospray ionization was used with a triple quadrupole mass spectrometer for the determination of threshold dissociation energies upon application of increasing collision energies. Various data analysis techniques for the determination of dissociation energies are discussed to assess the most suitable method for determining the stabilities of the ionophore-metal complexes studied here. In all cases only the relative stabilities of different complexes may be obtained by the method presented in this study, which does not assess absolute gas phase dissociation energies. Correction factors have been applied, however, to account for the energy conversion during collisions of different metal complexes and the varying degrees of freedom of different sized ligands, allowing for the comparison of the stabilities of different ionophores with like-metals. The measured threshold dissociation energies were compared with respect to the ionic radius of the metal cation, revealing a maximum stability for the K+ complexes of both lasalocid and monensin. A striking decrease in the stabilities of the Rb+ and Cs+ complexes was observed and is believed to be related to a decreasing degree of coordination that the ionophores can accomplish with the larger metals.
Publication date
PublisherSpringer International Publishing AG
Copyright noticeCopyright © 2005 American Society for Mass Spectrometry
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada
Peer reviewedYes
NRC number1662
NPARC number3538047
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Record identifierf2afd150-32f5-4c3e-b50c-5c45e1ea47a1
Record created2009-03-01
Record modified2016-05-09
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