Predicting pharmaceutical manufacturing changes using molecular laser-induced breakdown spectroscopy and chemometrics

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ConferenceIFPAC 2008, January 27-30, 2008, Baltimore, Maryland, USA
Pages# of pages: 1
AbstractIn many pharmaceutical manufacturing applications, Laser Induced Breakdown Spectroscopy (LIBS) makes possible at-line rapid measurements of many formulation ingredients as well as the possibility of stand-off analysis, in-situ, in-line and on line process monitoring. These capabilities make LIBS an attractive PAT sensor technology that can be introduced virtually everywhere in the pharmaceutical manufacturing process. Molecular Laser-Induced Breakdown Spectroscopy (MO-LIBS) uses the molecular band emission of small diatomic fragments and chemometrics to establish predictive model that allow quantitative measurements. This innovative approach allows a complete simultaneous formulation ingredients analysis as well as the prediction of pharmaceutical manufacturing changes. The results obtained in this work highlight the potential for MO-LIBS to be more widely applied to process monitoring and quality control of pharmaceutical products.
Publication date
AffiliationNRC Industrial Materials Institute; National Research Council Canada
Peer reviewedNo
NRC number54242
NPARC number18335899
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Record identifierf360f69a-e20a-451d-b679-4980084943a0
Record created2011-07-29
Record modified2016-05-09
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