Glucose: glycogen a-4-glucosyltransferase (EC 2.4.1.11) and a-1,4-glycan: orthophosphate glucosyltransferase (EC 2.4.1.1) activity in rat brain in experimental ischemia

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DOIResolve DOI: http://doi.org/10.1007/BF00684601
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TypeArticle
Journal titleActa Neuropathologica
ISSN0001-6322
1432-0533
Volume19
Pages242248; # of pages: 7
Subjectglycogen; UDP G-G glucosyltransferase; glycogen phosphorylase; cerebral ischemia
AbstractThe activity of UDPglucose-glycogen glucosyltransferase and of glycogen phosphorylase in the brain of rats subjected to experimental ischemia was in vestigated. A transient increase in UDPglucose-glycogen glucosyltransferase activity was noted in the period between the 12th and 48th h after the operation. The enzyme level returned to its initial value after 72 h of ischemia. Glycogen phosphorylase activity was studied in preparations with and without 5′ AMP added. The enzyme activity increased from the 12th to the 72nd h of the experiment and returned to normal after 120 h in the brain of rats with ligated arteries, and also in the control group subjected to sham operation. In normal rats and those anaesthetised only, no changes were found in brain glycogen phosphorylase activity. The enhanced UDPglucose-glycogen glucosyltransferase activity may be responsible for the glycogen deposition in rat brain in experimental ischemia.
Publication date
PublisherSpringer
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NRC numberSMIALEK1971
NPARC number9377374
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Record identifierf4bbe341-9d29-4db0-b37c-c42bd73764c1
Record created2009-07-10
Record modified2017-04-11
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