The capsular polysaccharide and lipopolysaccharide structures of two carbapenem resistant Klebsiella pneumoniae outbreak isolates

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2012.12.018
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TypeArticle
Journal titleCarbohydrate Research
ISSN0008-6215
Volume369
Pages69; # of pages: 4
SubjectCapsular polysaccharides; CRKP; Klebsiella pneumoniae; KPC; LPS; National Institutes of Health; O-specific polysaccharides; Therapeutic solutions; Organic compounds; Structure (composition); Synthesis (chemical); Bacteria; carbapenem; lipopolysaccharide; polysaccharide; article; bacterium isolate; carbohydrate analysis; Klebsiella pneumoniae; methylation; molecular typing; nonhuman; nuclear magnetic resonance spectroscopy; polyacrylamide gel electrophoresis; priority journal; silver staining; Anti-Bacterial Agents; Carbapenems; Drug Resistance, Bacterial; Klebsiella pneumoniae; Lipopolysaccharides; Polysaccharides, Bacterial; Klebsiella pneumoniae
AbstractCarbapenem resistant Klebsiella pneumoniae (CRKP) are isolated with increasing frequency, especially from immunocompromized patients. The capsular polysaccharide (CPS) types of CPKP were not determined. Investigation of two CRKP isolates from a 2011 outbreak at the Clinical Center, the National Institutes of Health, identified a new capsular type shared by the two isolates, similar to K. pneumonia K19 and K34 but structurally different than any published K. pneumoniae CPS repeating unit: The LPS of the two isolates was found to have no O-specific polysaccharide and the chemical structure of the core oligosaccharides agreed with the published data. If this structure type will be prevalent among CPKP isolates, our findings could facilitate rapid diagnosis and help to develop new therapeutic solutions to this antibiotic resistant pathogen. © 2013 Elsevier Inc. All rights reserved.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270600
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Record identifierf4dba8af-edfa-4602-bcbe-a58074b33bce
Record created2014-02-17
Record modified2016-05-09
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